.Nature Medication, Posted online: 13 September 2024 doi:10.1038/ s41591-024-03261-7In the non-randomized stage 3b/4 DESTINY-Breast12 research, trastuzumab deruxtecan (T-DXd) procedure of people along with HER2+ state-of-the-art bosom cancer cells and also energetic or stable brain metastases presented regular intracranial activity and also systemic efficacy of T-DXd.